Evidence that antibiotic administration is effective in treating a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency

Cervical insufficiency is a risk factor for spontaneous mid-trimester abortion or early preterm birth. Intra-amniotic infection has been reported in 8-52% of such patients, and intra-amniotic inflammation in 81%. Therefore, it is possible that antibiotic administration can eradicate intra-amniotic infection/inflammation and improve pregnancy outcome.