Kenichiro Motomura, M.D., Ph.D.

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Academic Affiliations

Assistant Professor (Research)

  • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology
  • Wayne State University School of Medicine, Perinatology Research Branch, NICHD/NIH/DHHS
Education
  • M.D., School of Medicine, Gifu University, Gifu, Japan
  • Ph.D. – Pediatrics, Department of Pediatrics, Kochi Medical University, Kochi, Japan
    • Postdoctoral Fellow – Maternal-Fetal Immunobiology Unit, Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    • Research Fellow – Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    • Senior Residency – Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan
    • Junior Residency – Yokosuka Kyosai Hospital, Yokosuka, Japan
      Research Accomplishments
      • Published articles investigating the causal link between preterm birth and intra-amniotic infection, as well as sterile intra-amniotic inflammation.
      Research Interests
      • Primary research interest: the mechanisms of and treatments for intra-amniotic inflammation- induced preterm labor and birth.
      • Specific interests:
        • The role of the NLRP3 inflammasome in intra-amniotic inflammation-induced preterm labor and birth.
        • The host-microbe interaction in the amniotic cavity.
        Awards & Recognition
        • 2016 New Investigator Travel Award
          Presented at the 13th Congress of the International Society for Immunology of Reproduction Erfurt, Germany
        • 2015 Y. W. Loke New Investigator Travel Award
          Presented at the International Federation of Placenta Associations Meeting
          Queensland, Australia
        Select Publications
        • Motomura K, Romero R, Tarca AL, Galaz J, Bhatti G, Done B, Arenas-Hernandez M, Levenson D, Slutsky R, Hsu CD, Gomez-Lopez N. Pregnancy-specific transcriptional changes upon endotoxin exposure in mice. J Perinatal Med; accepted, in press.
        • Motomura K, Romero R, Garcia-Flores V, Leng Y, Xu Y, Galaz J, Slutsky R, Levenson D, Gomez-Lopez N. The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome. Mol Hum Reprod. 2020 Jul 9:gaaa054. PMID: 32647859
        • Motomura K, Romero R, Xu Y, Theis KR, Galaz J, Winters AD, Slutsky R, Garcia-Flores V, Zou C, Levenson D, Para R, Ahmad MM, Miller D, Hsu CD, Gomez-Lopez N. Intra-amniotic infection with Ureaplasma parvum causes preterm birth and neonatal mortality that are prevented by treatment with clarithromycin. mBio. 2020 Jun 23; 11:e00797-20. PMID: 32576673
        • Theis KR, Romero R, Greenberg JM, Winters AD, Garcia-Flores V, Motomura K, Ahmad MM, Galaz J, Arenas-Hernandez M, Gomez-Lopez N. No consistent evidence for microbiota in murine placental and fetal tissues. mSphere. 2020 Feb 26; 5:e00933-19. PMID: 32102944
        • Theis KR, Romero R, Motomura K, Galaz J, Winters AD, Pacora P, Miller D, Slutsky R, Florova V, Levenson D, Para R, Varrey A, Kacerovsky M, Hsu CD, Gomez-Lopez N. Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes. J Perinat Med. 2020 Feb 25; 48:115-131. PMID: 31927525
        • Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R. Inflammasomes: their role in normal and complicated pregnancies. J Immunol. 2019 Dec 1; 203:2757-2769. Review. PMID: 31740550
        • Gomez-Lopez N, Romero R, Galaz J, Xu Y, Panaitescu B, Slutsky R, Motomura K, Gill N, Para R, Pacora P, Jung E, Hsu CD. Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation. Am J Reprod Immunol. 2019 Nov; 82:e13171. PMID: 31323170
        • Nakashima A, Cheng SB, Kusabiraki T, Motomura K, Aoki A, Ushijima A, Ono Y, Tsuda S, Shima T, Yoshino O, Sago H, Matsumoto K, Sharma S, Saito S. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Sci Rep. 2019 Aug 7; 9:11466.PMID: 31391477
        • Morita H, Kubo T, Rückert B, Ravindran A, Soyka MB, Rinaldi AO, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O'Mahony L, Honda K, Nakae S, Saito H, Mjösberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA. Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid. J Allergy Clin Immunol. 2019 Jun; 143:2190-2201.e9. PMID: 30682454
        • Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, Jung E, Hassan SS, Hsu CD. Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. J Perinat Med. 2019 Apr 24; 47:276-287. PMID: 30412466
        • Morita H, Tamari M, Fujiwara M, Motomura K, Koezuka Y, Ichien G, Matsumoto K, Ishizaka K, Saito H. IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice. J Allergy Clin Immunol. 2019 Mar; 143:1261-1264.e6. PMID: 30471303
        • Miller D, Motomura K, Garcia-Flores V, Romero R, Gomez-Lopez N. Innate lymphoid cells in the maternal and fetal compartments. Front Immunol. 2018 Oct 26; 9:2396. Review. PMID: 30416502
        • Motomura K, Okada N, Morita H, Hara M, Tamari M, Orimo K, Matsuda G, Imadome KI, Matsuda A, Nagamatsu T, Fujieda M, Sago H, Saito H, Matsumoto K. A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro. PLoS One. 2017 May 19; 12:e0177994. PMID: 28542501
        • Motomura K, Ganchimeg T, Nagata C, Ota E, Vogel JP, Betran AP, Torloni MR, Jayaratne K, Jwa SC, Mittal S, Dy Recidoro Z, Matsumoto K, Fujieda M, Nafiou I, Yunis K, Qureshi Z, Souza JP, Mori R. Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health. Sci Rep. 2017 Mar 10; 7:44093. PMID: 28281576
        • Sasaki A, Motomura K, Suyama F, Nagasawa J, Hisano M, Ito R, Miyazaki O, Nakazawa A, Ito Y, Kasahara M, Asai A, Matsumoto K, Sago H, Yamaguchi K. Fetal magnetic resonance imaging detection of liver iron deposition in neonatal hemochromatosis during prenatal therapy. J Pediatr Gastroenterol Nutr. 2016 Nov; 63:e121. PMID: 27331656
        • Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers. Immunity. 2015 Jul 21; 43:175-86. PMID: 26200013
        • Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014 Oct; 134:824-830.e6. Clinical trial. PMID: 25282564

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